I think that He'd probably be able to handle most guys right off the bat. And after a lttle to atune to fighting with much larger guys, he'd be able contend. His ground is good, but alot of the big guys have good ground too.
However if Anderson pulled an Anderson and kept it standing, KOs all the way to the top. He's just too fast and his technique is just too smooth striking for a heavy hitting banger to stand for more than the time it takes for an Anderson combination.