So, after now playing Skyrim, Uncharted 3, Gears of War 3, MW3, Portal 2, I can honestly say that, as much of a giant Skyrim fan as I am, none of these games beat Deus Ex.
I had such a blast playing that. It has a great story, great side quests, awesome combat, crazy good RPG elements, the inventory is great, art/graphical style is very good, and I was more surprised by that game than any other game this year in terms of quality.
“Anna, my strong, terrifying Anna.” -Cas
"You lack the requisite spine and testicular fortitude to study under me" -Elodin