Realistically Lee has to be saved or the next episode should be his last. Duck fell ill almost instantly when he got bit to the point he really didn't move that much. Obviously they drove all night before he finally died and perhaps they could squeeze Lee into 2 episodes but i don't know.. Can't wait for the next one.
I'm not really interested on new main characters and a season 2 without Lee tbh. Clem putting away Lee will definitely be one of my "the video game moments" of all time. The bond they've been able to build between these two is quite amazing to me.