I think Cain/Overeem (provided he wins) and JDS/Werdum 2 make the most sense. Then have the winners fight each other. If lightning strikes and Bigfoot beats Overeem, then do Cain/Werdum and JDS/Overeem.
Do Jim Miller vs. Pettis/Cerrone loser and Diaz vs. Lauzon. None of the guys scream "title shot" at the moment, so it's almost like doing fights to clear out the middle/upper pack of the division.