I was talking to some people the other day about this very thing. Except I said what if Werdum and Reem both lose?
Then you have to take a serious look at Hunt vs Struve IMO. Do you give Bigfoot or Nog a rematch at Cain? Do you go with JDS 3 this early? Shitty situation but IMO the best possible options under this scenario are Hunt-Struve winner and JDS 3. Not much else out there. If you go rematch you probably have to go with Nog over Bigfoot since not only is Nog a legend but that fight was much longer ago.