Not a good idea imo. It is an intensely storybased series, and the third is a culmination of the overall plot arc. It's like watching the finale episode of a show without watching the earlier stuff. It won't have the same impact as enjoying them in the intended order.
Just started ME1 - it's moving kinda slow though, the navigation isn't always very clear
Still good game though.
Just outed that Spectre dude and I'm on my way to explore the galaxy looking for him I think