It is possible, but I think one punch from him, landing ANYWHERE on her, would hurt her badly, even if she has the chance to grab him. I just don't see she being able to close distance, take him down and sub him without being fiercely tagged repeatedly as this is his specialty and a woman would have less resistance to take power shots from a man, me thinks.
Anyway, I would have no problem seeing this challenge fight IF she signed for it. Once someone signed, there's no cowardliness no more. I am sure the difference in strength would be smaller than the one between Royce and Dan Severn.