So, after now playing Skyrim, Uncharted 3, Gears of War 3, MW3, Portal 2, I can honestly say that, as much of a giant Skyrim fan as I am, none of these games beat Deus Ex.
I had such a blast playing that. It has a great story, great side quests, awesome combat, crazy good RPG elements, the inventory is great, art/graphical style is very good, and I was more surprised by that game than any other game this year in terms of quality.
"You lack the requisite spine and testicular fortitude to study under me"
"You do not know the first note of the music that moves me."